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The Kreeger Lab

The Kreeger lab utilizes systems biology and tissue engineering to analyze cellular behavior in a variety of biological contexts. We utilize an iterative approach, where we develop model culture systems that allow us to study a disease in a controlled environment, use high-throughput experimental methods to gather information about the cellular signaling network and cellular responses, and employ computational models to interpret the data. Ultimately, our models will be utilized to identify new drug targets, match patients to the most effective drugs, and identify methods to direct cellular behavior.

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New study from the Kreeger Lab links growth factor-induced tumor cell proliferation to increasing collagen I density

July 2020 –  In HGSOC patient samples, it was determined that TGFβ1 present in ascites fluid activates omental fibroblasts to deposit collagen I. Using analyses of HGSOC patient samples, an in vitro model of the metastatic ovarian cancer microenvironment with pathologically relevant collagen I densities was designed. Using this model, it was found that HB-EGF-induced proliferation was […]

Kreeger lab publishes new study linking substrate curvature to cell invasion in an ovarian cortical inclusion cyst model

November 2019 – From this work, it is shown that increased fallopian tube epithelial (FTE) cell invasion is associated with increased curvature in an in vitro lumen model. Through the use of a finite element model of cell-cell tension, it was found that cell-cell connections were critical for initiation of invasion. After this initiation step, […]

Kreeger Lab publishes new study on the impact of proteomics in BRAF-V600E basket trial computational models to predict tumor cell drug sensitivity

October 2019 – The results of this study, published in BMC Cancer, suggest that the inclusion of proteomics into BRAF-V600E basket trials improve drug response predictions and may help identify novel co-therapies. These findings can be found here.

Congratulations Dr. Fleszar!

August 2019 – Kreeger lab graduate student Andy Fleszar successfully defended his dissertation, “Follicular fluid, ovarian cortical inclusion cysts, and substrate curvature increase the cancerous progression of fallopian tube epithelial cells” in the Department of Biomedical Engineering. Congratulations Andy!

Kreeger Lab publishes study elucidating new mechanism linking scaffold stiffness and breast cancer invasion

July 2019 – The Kreeger Lab, in collaboration with Dr. Kristyn Masters’ Lab, has elucidated a new mechanism linking scaffold stiffness and breast cancer cell invasion. This mechanism involves an increased expression of invadapodia protein Mena in high stiffness microenvironments, leading to the production of a fibronectin halo around breast cancer spheroids and promoting invasion. […]

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