Publications
C. Renner, M.R. Visetsouk, P.K. Kreeger, K.S. Masters. “Multispectral staining and analysis of extracellular matrix.” Methods Mol Biol. 2424:105-119. 2022 [PubMed]
H.M. Micek, M.J. Carroll, L. Barroilhet, P.K. Kreeger. “Processing and analysis of ascites.” Methods Mol Biol. 2424:95-104. 2022 [PubMed]
C. Renner, C. Gomez, M.R. Visetsouk, I. Taha, A. Khan, S.M. McGregor, P. Weisman, A. Naba, K.S. Masters, P.K. Kreeger. “Multi-modal Profiling of the Extracellular Matrix of Human Fallopian Tubes and Serous Tubal Intraepithelial Carcinomas.” J Histochem Cytochem. 70(2):151-168. 2022 [PubMed]
APL Bioeng. 5(4):046101. 2021 [PubMed]
J. Zhang, N. Yang, P.K. Kreeger, J. Notbohm. “Topological defects in the mesothelium suppress ovarian cancer cell clearance.” APL Bioeng. 5(3):036103. 2021. [PubMed]
H.M. Micek, M.R. Visetsouk, A.J. Fleszar, P.K. Kreeger. “The many microenvironment of ovarian cancer.” Adv Exp Med Biol. 1296:199-213. 2020. [PubMed]
H.M. Micek, M.R. Visetsouk, K.S. Masters, P.K. Kreeger. “Engineering the extracellular matrix to model the evolving tumor microenvironment.” iScience. 23(11):101742. 2020. [PubMed]
P.K. Kreeger, A. Brock, H.C. Gibbs, K.J. Grande-Allen, A.H. Huang, K.S. Masters, P. Rangamani, M.R. Reagan, S.L. Servoss. “Ten simple rules for women principal investigators during a pandemic.” PLoS Computational Biology. 16(10):e1008370. 2020. [PubMed]
K.C. Fogg, A.E. Miller, Y. Li, W. Flanigan, A. Walker, A. O’Shea, C. Kendziorski, P.K. Kreeger. “Ovarian cancer cells direct monocyte differentiation through a non-canonical pathway.” BMC Cancer. 20(1):1008. 2020. [PubMed]
K.C. Fogg, C.M. Renner, H.M. Christian, A. Walker, L. Marty-Santos, A. Khan, W.R. Olson, C. Parent, A. O’Shea, D.M. Wellik, P.S. Weisman, P.K. Kreeger. “Ovarian Cells Have Increased Proliferation in Response to Heparin-Binding Epidermal Growth Factor as Collagen Density Increases.” Tissue Engineering Part A. 26(13-14):747-758. 2020. [PubMed]
A.J. Berger, C.M. Renner, I. Hale, X. Yang, S.M. Ponik, P.S. Weisman, K.S. Masters, and P.K. Kreeger. “Scaffold stiffness breast cancer cell invasion via EGFR-linked Mena upregulation and matrix remodeling.” Matrix Biology. 85-86:80-93. 2020. [PubMed]
M.J. Carroll, C.R. Parent, D. Page, P.K. Kreeger. “Tumor cell sensitivity to vemurafenib can be predicted from protein expression in a BRAF-V600E basket trial setting.” BMC Cancer. 19(1):1025. 2019. [PubMed]
A.J. Fleszar, A. Walker, P.K. Kreeger, J. Notbohm. “Substrate curvature induces fallopian tube epithelial cell invasion via cell-cell tension in a model of ovarian cortical inclusion cysts.” Integrative Biology. 11(8):342-352. 2019. [PubMed]
C.S. Kim, X. Yang, S. Jacobsen, K.S. Masters, and P.K. Kreeger. “Leader cell PLCγ1 activation during keratinocyte collective migration is induced by EGFR localization and clustering.” Bioengineering & Translational Medicine. e10138. 2019. [PubMed]
K.C. Fogg, W.R. Olson, J.N. Miller, A. Khan, I. Hale, P.S. Weisman, and P.K. Kreeger. “Alternatively activated macrophage-derived secretome stimulates ovarian cancer spheroid spreading through a JAK2/STAT3 pathway.” Cancer Letters. 458:92-101. 2019. [PubMed]
M.J. Carroll, K.C. Fogg, H.A. Patel, H.B. Krause, A. Mancha, M.S. Patankar, P.S. Weisman, L. Barroilhet, and P.K. Kreeger. “Alternatively activated macrophages upregulate mesothelial expression of P-selectin to enhance adhesion of ovarian cancer cells.” Cancer Research. 78(13):3560-3573. 2018. [PubMed]
A.J. Fleszar, A Walker, V. Porubsky, W. Flanigan, D. James, P.J. Campagnola, P.S. Weisman, and P.K. Kreeger. “The extracellular matrix of ovarian cortical inclusion cysts modulates invasion of fallopian tube epithelial cells.” APL Bioengineering 2, 031902. 2018. [Link]
P.K. Kreeger, L.E. Strong, K.S. Masters. “Engineering approaches to study cellular-decision making.” Annual Reviews of Biomedical Engineering. 20:49-72. 2018 [PubMed]
K.S. Masters, P.K. Kreeger. “Ten simple rules for developing a mentor-mentee expectations document.” PLoS Comp Biol. 13(9):e1005709. 2017. [PubMed]
D.L. Bourgeois, P.K. Kreeger. “Partial Least Squares Regression Models for the Analysis of Kinase Signaling.” Methods Mol Biol. 1636:523-533, 2017. [PubMed]
A.J. Berger, K.M. Linsmeier, P.K. Kreeger, K.S. Masters. “Decoupling the effects of stiffness and fiber density on cellular behaviors via an interpenetrating network of gelatin-methacrylate and collagen.” Biomaterials. Oct;141:125-135, 2017. [PubMed]
M.J. Carroll, A. Kapur, M. Felder, M.S. Patankar, P.K. Kreeger. “M2 macrophages induce ovarian cancer cell proliferation via a heparin binding epidermal growth factor/matrix metalloproteinase 9 intercellular feedback loop.” Oncotarget. 7(52):86608-86620, 2016. [PubMed]
C.S. Kim, I.P. Mitchell, A.W. Desotell, P.K. Kreeger, K.S. Masters. “Immobilized epidermal growth factor stimulates persistent, directed keratinocyte migration via activation of PLCγ1.” FASEB J. 30(7):2580-90, 2016. [PubMed]
D. Tian, I. Mitchell, P.K. Kreeger. “Quantitative analysis of the impact of insulin-like growth factor 2 receptor and IGF binding proteins on IGF1R phosphorylation.” BMC Systems Biology. 10:15, 2016. [PubMed]
L.E. Wickert, S. Pomerenke, I. Mitchell, K.S. Masters, P.K. Kreeger. “Hierarchy of cellular decisions in collective behavior: Implications for wound healing.” Scientific Reports. 6:20139, 2016. [PubMed]
D.L. Bourgeois, K.A. Kabarowski, V.L. Porubsky, P.K. Kreeger. “High-grade serous ovarian cancer cell lines exhibit heterogeneous responses to growth factor stimulation.” Cancer Cell Intl. 15: 112, 2015. [PubMed]
J. Kimble, W.M. Bement, Q. Chang, B.L. Cox, N.R. Drinkwater, R.L. Gourse, A.A. Hoskins, A. Huttenlocher, P.K. Kreeger, P.F. Lambert, M.R. Mailick, S. Miyamoto, R.L. Moss, K.M. O’Connor-Giles, A. Roopra, K. Saha, H.S. Seidel. “Strategies from UW-Madison for rescuing biomedical research in the US.” ELife. 4: e09305, 2015. [PubMed]
D. Tian, N.M. Solodin, P. Rajbhandari, K. Bjorklund, E.T. Alarid, P.K. Kreeger. “A kinetic model identifies phosphorylated estrogen receptor-α (ERα) as a critical regulator of ERα dynamics in breast cancer.” The FASEB Journal. 29(5), p. 2022-2031, 2015. [PubMed]
D. Tian, P.K. Kreeger. “Analysis of the quantitative balance between insulin-like growth factor (IGF)-1 ligand, receptor, and binding protein levels to predict cell sensitivity and therapeutic efficacy.” BMC Systems Biology. 8: 98, 2014. [PubMed]
K. Pollock, T.J. Jaraczewski, M.J. Carroll, D.I. Lebovic, P.K. Kreeger. “Endometriotic epithelial cell response to macrophage-secreted factors is dependent on extracellular matrix context.” Cellular and Molecular Bioengineering. 7, p. 409-420, 2014. [Article]
M.J. Carroll, L.E. Stopfer, P.K. Kreeger. “A simplified culture system to examine soluble factor interactions between mammalian cells.” Chemical Communications. 50, p. 5279-5281, 2014. [PubMed]
P.K. Kreeger. “Using partial least squares regression to analyze cellular response data.” Science Signaling. 6, p. tr7, 2013. [PubMed] [Article]
R. Liu, K.Z. Vang, P.K. Kreeger, S.H. Gellman, K.S. Masters. “Experimental and computational analysis of cellular interactions with nylon-3-bearing substrates.” Journal of Biomedical Materials Research: Part A. 100A, p. 2750-2759, 2012. [PubMed]
R.D. Prasasya, K. Vang, P.K. Kreeger. “A multivariate model of ErbB network composition predicts ovarian cancer cell response to canertinib.” Biotechnology and Bioengineering. 109, p 213-224, 2012. spotlighted on p fmvi. [PubMed]
R.D. Prasasya, D. Tian, P.K. Kreeger. “Analysis of cancer signaling networks by systems biology to develop therapies.” Seminars in Cancer Biology. 21, p 200-206, 2011. [PubMed]
P.K. Kreeger, Y. Wang, K.M. Haigis, D.A. Lauffenburger. “Integration of multiple signaling pathway activities resolves K-RAS / N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation.” Integrative Biology. 2, p 202-208, 2010. [PubMed]
P.K. Kreeger, D.A. Lauffenburger. “Cancer systems biology: a network modeling perspective.” Carcinogenesis. 31, p 2-8, 2010. [PubMed]
P.K. Kreeger, R. Mandhana, S.K. Alford, K.M. Haigis, D.A. Lauffenburger. “RAS mutations impact TNF-Induced apoptosis responses of colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects.” Cancer Research. 69, p 8191-8199, 2009. [PubMed]
M. Xu, P.K. Kreeger, L.D. Shea, and T.K. Woodruff. “Tissue engineered follicles produce live, fertile offspring.” Tissue Engineering. 12, p 2739-2746, 2006. [PubMed]
Highlighted in Nature Medicine [PubMed]
S.K. Bristol-Gould, P.K. Kreeger, C.G. Selkirk, S.M. Kilen, K.E. Mayo, L.D. Shea, and T.K. Woodruff. “Fate of the initial follicle pool: empirical and mathematical evidence supporting its sufficiency for adult fertility.” Developmental Biology. 298, p 149-154, 2006. [PubMed]
Highlighted in Nature Medicine [PubMed]
S.K. Bristol-Gould, P.K. Kreeger, C.G. Selkirk, S.M. Kilen, R.W. Cook, J.L. Kipp, L.D. Shea, K.E. Mayo, and T.K. Woodruff. “Postnatal regulation of germ cells by activin: the establishment of the initial follicle pool.” Developmental Biology. 298, p 132-148, 2006. [PubMed]
Highlighted in Nature Medicine [PubMed]
P.K. Kreeger, J.W. Deck, T.K. Woodruff, and L.D. Shea. “The in vitro regulation of ovarian follicle development using alginate-extracellular matrix gels.” Biomaterials. 27, p 714-723, 2006. [PubMed]
P.K. Kreeger, N.N. Fernandes, T.K. Woodruff, and L.D. Shea. “Regulation of mouse follicle development by follicle stimulating hormone in a three-dimensional in vitro culture system is dependent on follicle stage and dose.” Biology of Reproduction. 73, p 942-950, 2005. [PubMed]
P.K. Kreeger, T.K. Woodruff, and L.D. Shea. “Murine granulosa cell morphology and function are regulated by a synthetic Arg-Gly-Asp matrix.” Molecular and Cellular Endocrinology. 205, p 1-10, 2003. [PubMed]
